Searchable abstracts of presentations at key conferences in endocrinology

ea0016p21 | Adrenal | ECE2008

11β-hydroxysteroid dehydrogenase 2 activity is elevated in extreme obese subjects and negatively associated with insulin sensitivity

Mussig Karsten , Remer Thomas , Haupt Axel , Gallwitz Baptist , Fritsche Andreas , Haring Hans-Ulrich , Maser-Gluth Christiane

Objectives: Alterations in glucocorticoid (GC) metabolism may contribute to the development of obesity and insulin resistance. We aimed to study the role of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in human adiposity, paying special attention to the association between altered GC metabolism and insulin sensitivity.Design: In 24-h urine samples of 72 extremely obese (mean BMI 45.5±1.1 kg/m2), but otherwise healthy patie...